Jones, Martin Alexander
November 22, 2018
Transcription factors (TF’s) are special types of proteins in living organisms that regulate the expression of genes. Gene regulation primarily relies on the affinity of proteins for operable binding sites in the DNA, often involving more than one transcription factor and several TF – DNA binding reactions. Binding sites are not explicitly unique however, sometimes involving varying sequences of nucleotide base pairs. The protein’s ability to distinguish operable sites from non-sites (or what have been termed “pseudosites” (von Hippel & Berg, 1986)) is its specificity.
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