Category:
Research Papers
Sub-Category:
Biology / Medicine
Date Published:
June 16, 2025
Abstract:
Stem cells were declared among the top promising discoveries of the 20th century. Extended research on fetal stem cells was started in 1973, after the clinical success of bone marrow stem cell transplantation (Bone Marrow Transplantation — BMT).
By that time, Pluripotent Fetal Stem Cells from aborted tissues (FSC) were the only probable alternative for BMT. The FSCs were regarded as a more efficient and strong kind of stem cells. The scientific race for creating a clinical method for efficient and safe clinical fetal stem cell transplantation started immediately in nearly 20 countries (the topic was called Fetal Liver Transplantation – FLT). Over the next 15 years, about one thousand clinical transplantations have been performed worldwide. Multiple results were published in top medical journals and reported at two international conferences. Despite several promising clinical cases, the overall clinical results were rather modest. Initial hopes and excitement turned to despair, and by the early 90s, clinical FLT was practically abandoned. Such an outcome may be attributed to the lack of an effective method for the clinical use of FSC. The first efficient, safe, and robust method for clinical transplantation of Pluripotent Fetal Stem Cells was invented only after two decades of research—in 1991—by Prof. Alexander Smikodub (1948–2009) from the National Medical University (Kyiv, Ukraine).
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